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排序方式: 共有209条查询结果,搜索用时 234 毫秒
201.
Ibrahim Ozan Tekeli Erdinc Turk Duygu Durna Corum Orhan Corum Fatma Ceren Kirgiz Fatih Sakin Kamil Uney 《Journal of veterinary pharmacology and therapeutics》2020,43(5):440-447
The pharmacokinetics of cefquinome (2 mg/kg every 24 hr for 5 days) was determined following intramuscular administration alone and co-administration with ketoprofen (3 mg/kg every 24 hr for 5 days) in goats. Six goats were used for the study. In the study, the crossover pharmacokinetics design with 20-day washout period was performed in two periods. Plasma concentrations of cefquinome were assayed using high-performance liquid chromatography by ultraviolet detection. The mean terminal elimination half-life (t1/2ʎz), area under the concentration–time curve (AUC0–24), peak concentration (Cmax), apparent volume of distribution (Vdarea/F), and total body clearance (CL/F) of cefquinome after the administration alone were 4.85 hr, 11.06 hr*µg/ml, 2.37 µg/mL, 1.23 L/kg, and 0.17 L/h/kg after the first dose, and 5.88 hr, 17.01 hr*µg/mL, 3.04 µg/mL, 0.95 L/kg, and 0.11 L/h/kg after the last dose. Ketoprofen significantly prolonged t1/2ʎz of cefquinome, increased AUC0–24 and Cmax, and decreased Vdarea/F and CL/F. Cefquinome exhibited low accumulation after the administration alone and in combination with ketoprofen. These results indicated that ketoprofen prolonged the elimination of cefquinome in goats. The 24-hr dosing intervals at 2 mg/kg dose of cefquinome, which co-administered with ketoprofen, may maintain T> minimum inhibitory concentration (MIC) values above 40% in the treatment of infections caused by susceptible pathogens with the MIC value of ≤0.75 μg/ml in goats with an inflammatory condition. 相似文献
202.
Joseph Hill Jessica Lawrence Corey Saba Michelle Turek Brittany Feldhaeusser Sheryl Coutermarsh-Ott Jamie Barber Jo Smith Robert Gogal Jr 《Research in veterinary science》2014
Feline injection site sarcoma (ISS) is a locally invasive tumor, in which surgical treatment is frequently combined with radiation or chemotherapy to improve tumor control. The focus of this study was to evaluate the cytotoxic effects of doxorubicin or etoposide on a feline injection site sarcoma cell line (JB) and to assess the impact of combining these drugs on cell death and cell cycle. Both single agent and combination drug administration increased cell death and significantly reduced the number of viable cells. Cells in G0/G1 were significantly reduced while the G2/M fraction was significantly increased following treatment. Collectively, combining doxorubicin and etoposide at the lower EC yielded comparable results to the EC50 of either drug alone in degree of cytotoxicity, level of apoptosis, and % of cells in G2/M. The results of this study indicate that doxorubicin and etoposide alone and in combination differentially alter ISS cell viability and cycle. 相似文献
203.
目的 探讨痰热清注射液对社区获得性肺炎临床疗效及血清降钙素原(PCT)水平的影响。方法 选择116例社区获得性肺炎患者为研究对象,依据随机数字表法分为试验组和对照组各58例。对照组采用抗感染、化痰、对症等常规治疗,试验组在此基础上联合痰热清注射液治疗,观察两组患者的体温、临床症状、PCT水平变化。结果 试验组总有效率为94.8%,对照组为81.0%,试验组总有效率明显高于对照组,差异有统计学意义(P<0.05);治疗后两组血清PCT水平均降低(P<0.05),但试验组较对照组降低明显,差异有统计学意义(P<0.05)。结论 痰热清注射液能显著改善社区获得性肺炎患者临床症状,提高临床疗效,下调血清PCT浓度,且无明显不良反应发生。 相似文献
204.
硫酸盐还原菌的筛选及生理特性研究 总被引:1,自引:0,他引:1
[目的]为使用硫酸盐还原菌处理废水提供理论依据。[方法]利用硫酸盐还原菌选择培养基从生产赤霉素产生的废水中筛选硫酸盐还原菌。依据不同菌株对硫酸根的降解效率,对筛选出的菌株进行复筛。选取对硫酸盐降解效果最好的菌株,研究温度、pH值、接种量等对其生理活性的影响。[结果]从供试废水中共筛选出8种硫酸盐还原菌,其对硫酸根的降解效率为26.22%~87.75%。经综合分析,确定8号菌株为优势菌;不同接种量对其硫酸盐降解效率影响不大;温度和pH值对硫酸盐还原菌的影响较大,最适温度和pH值分别为35℃和7.5。[结论]8号菌株为优势菌,在最适条件下其对污水中硫酸盐的去除率达80%以上。 相似文献
205.
206.
207.
几种杀生剂的杀菌规律与作用机理探讨 总被引:1,自引:0,他引:1
[目的]为杀菌剂的复配增效提供参考。[方法]采用绝迹稀释法和平板涂抹计数法,探讨几类常用杀菌剂的杀菌规律和作用机理,并进行复配。[结果]优氯净、季铵盐和双季铵盐类对硫酸盐还原菌(SRB)的杀灭效果较好,甲醛效果较差。优氯净对异养菌的杀灭效果最好,甲醛和异噻唑啉酮效果稍差,其他杀菌剂效果较好。醛类、季铵盐类杀菌剂分别通过亲核加成反应、渗透和扩散杀灭细菌;优氯净以氧化作用而使微生物死亡。复配杀菌剂浓度为10mg/L时可以将细菌含量控制在油田回注水标准之内,50mg/L时能将硫酸盐还原菌和异养菌彻底杀灭。[结论]在充分了解杀菌剂作用机理的基础上,可以进行不同杀菌剂间的复配增效。 相似文献
208.
Soo Jin Baek Seong Yun Kim Seung Hwan Lee Jae Ryoun Youn Sung Hee Lee 《Fibers and Polymers》2008,9(6):747-754
In order to investigate effects of injection molding conditions on viscoelastic behavior and thermal deformation of film insert
molded (FIM) parts, injection molding was performed with various conditions such as injection speed, melt temperature, and
packing time. It was shown that variation of the warpage was decreased monotonically with increasing injection speed and exhibited
a bell-shaped curve as a function of melt temperature. Warpage variation was not affected by the packing time significantly
and the proportional relationship between warpage of the film insert molded part and shrinkage of the injection molded part
without film was observed. The FIM specimens produced with unannealed films showed the warpage reversal phenomenon (WRP) during
annealing and the magnitude of reversed warpage was affected significantly by the injection parameters and the extent of thermal
shrinkage of the unannealed film. Warpage of the FIM specimen was predicted by three dimensional numerical flow and stress
analyses and the predicted values showed a good agreement with the experimental results. 相似文献
209.